Yamaguchi T
Department of Hygiene, Miyazaki Medical College.
Nihon Rinsho. 1996 Jan;54(1):134-40.
The concentration of selenium (Se) and the activity of glutathione peroxidase (GSH-Px) in plasma and erythrocytes were measured in healthy men and in patients with Duchenne-type progressive muscular dystrophy (DMD). In healthy men, the Se concentration in erythrocytes showed a steep rise with aging and ascended gradually in plasma. The GSH-Px activity in both plasma and erythrocytes clearly increased with aging. The relationship between the Se concentration and the GSH-Px activity in healthy men showed a parallel rise with aging, but the coefficients of correlation were not very high (r = 0.44 and 0.56 in plasma and erythrocytes, respectively. In DMD patients, on the other hand, the Se concentration in erythrocytes decreased steeply with aging, and it decreased gradually in plasma. The GSH-Px activity in both plasma and erythrocytes apparently increased as in healthy men with aging, but the level was about 80% of that of healthy men. When selenite (Se+4) is added to the whole blood in vitro at 25 degrees C, it is rapidly taken up by erythrocytes (within several minutes) and is then released into plasma (a period of 30 min), then subsequent reuptake by erythrocytes is proceeded slowly. Our attention was attracted to the pattern of selenite release from erythrocytes of DMD patients.
我们检测了健康男性和杜氏型进行性肌营养不良症（DMD）患者血浆和红细胞中硒（Se）的浓度以及谷胱甘肽过氧化物酶（GSH-Px）的活性。在健康男性中，红细胞中的硒浓度随年龄增长急剧上升，血浆中的硒浓度则逐渐上升。血浆和红细胞中的GSH-Px活性均随年龄增长而明显增加。健康男性中硒浓度与GSH-Px活性之间的关系随年龄增长呈平行上升，但相关系数不是很高（血浆和红细胞中的r分别为0.44和0.56）。另一方面，在DMD患者中，红细胞中的硒浓度随年龄增长急剧下降，血浆中的硒浓度逐渐下降。血浆和红细胞中的GSH-Px活性与健康男性一样，随年龄增长明显增加，但水平约为健康男性的80%。当在25℃下将亚硒酸盐（Se+4）体外加入全血时，它会迅速被红细胞摄取（几分钟内），然后释放到血浆中（30分钟的时间段），随后红细胞的再次摄取过程缓慢。我们的注意力被DMD患者红细胞中亚硒酸盐的释放模式所吸引。
