慢性酒精中毒时缺糖转铁蛋白的变化

Changes of carbohydrate-deficient transferrin in chronic alcoholism.

作者信息

König P, Niederhofer H, Steurer H, Haller R, Wölfle R, Fritzsche H, Weiss P

机构信息

Landeskrankenhaus Rankweil, Department of Psychiatry I, Austria.

出版信息

Neuropsychobiology. 1995;32(4):192-6. doi: 10.1159/000119235.

DOI:10.1159/000119235

PMID:8587701

Abstract

Compared with other well established liver enzyme parameters, carbohydrate-deficient transferrin (CDT) offers a new method for the identification of chronic alcoholism. The dependence of CDT and alcoholism/abstinence was studied in 29 controls and 64 alcoholics (both groups comprising men and women). In contrast to the currently used parameters GOT, GPT, gammaGT, LDH and MCV, CDT measures chronic alcoholism exclusively. CDT is dependent on sex but not age. In chronic alcoholism its rate increases significantly, but drops quickly after a short time of abstinence. CDT variations may be a specific and sensitive indicator of alcoholism or abstinence and possibly the duration.

摘要

与其他已确立的肝脏酶参数相比，缺糖转铁蛋白（CDT）为慢性酒精中毒的识别提供了一种新方法。对29名对照者和64名酗酒者（两组均包括男性和女性）研究了CDT与酒精中毒/戒酒的相关性。与目前使用的参数谷草转氨酶（GOT）、谷丙转氨酶（GPT）、γ-谷氨酰转肽酶（gammaGT）、乳酸脱氢酶（LDH）和平均红细胞体积（MCV）不同，CDT专门用于检测慢性酒精中毒。CDT取决于性别而非年龄。在慢性酒精中毒时其水平显著升高，但在短时间戒酒之后迅速下降。CDT的变化可能是酒精中毒或戒酒以及可能的持续时间的一个特异性和敏感性指标。