Suto Y, Kodama F, Tanabe Y
Department of Radiology, Tottori University School of Medicine, Yonago, Japan.
Nucl Med Commun. 1995 Nov;16(11):905-11. doi: 10.1097/00006231-199511000-00005.
Twenty patients with 58 extrahepatic metastases of hepatocellular carcinoma (HCC) (41 bone, 5 lung, 6 peritoneum, 4 adrenal glands, 1 brain, 1 lymph node) underwent 123I-iodoamphetamine (123I-IMP) and gallium-67 (67Ga) scintigraphy. The rate of positivity with 123I-IMP planar imaging was 44% above the level of the diaphragm and 76% below the diaphragm, with an overall sensitivity of 62%. The combination of 123I-IMP scintigraphy and single photon emission tomography enabled positive visualization of an additional six metastatic foci: three in the adrenal glands, one in the peritoneum, one in the cranium and one in a rib. The rate of positivity with 67Ga planar imaging was 75% above the level of the diaphragm and 45% below the diaphragm, with an overall sensitivity of 58%. Our findings suggest that 123I-IMP is effective for detecting extrahepatic metastases of HCC, particularly those below the diaphragm.
20例伴有58处肝细胞癌（HCC）肝外转移灶（41处骨转移、5处肺转移、6处腹膜转移、4处肾上腺转移、1处脑转移、1处淋巴结转移）的患者接受了123I-碘安非他明（123I-IMP）和镓-67（67Ga）闪烁扫描。123I-IMP平面显像在膈肌水平以上的阳性率为44%，在膈肌水平以下为76%，总体敏感性为62%。123I-IMP闪烁扫描与单光子发射断层扫描相结合又使另外6个转移灶显影阳性：3个在肾上腺、1个在腹膜、1个在颅骨、1个在肋骨。67Ga平面显像在膈肌水平以上的阳性率为75%，在膈肌水平以下为45%，总体敏感性为58%。我们的研究结果表明，123I-IMP对检测HCC的肝外转移有效，尤其是膈肌水平以下的转移灶。
