McLean A R
Laboratoire des dynamiques lymphocytaires, Institut Pasteur, Paris, France.
Proc Biol Sci. 1995 Sep 22;261(1362):389-93. doi: 10.1098/rspb.1995.0164.
The evolution of vaccine-resistant strains of infectious agents is potentially a huge problem for their control by immunization. Yet, for many infectious diseases, it has been possible to drive them to the verge of extinction without vaccine escape mutants arising. This paper establishes a theoretical framework within which to ask why this should be so, what properties of vaccines allow this situation and what might happen in situations where vaccine escape mutants do arise.
传染病疫苗抗性菌株的进化对于通过免疫接种来控制这些疾病而言可能是一个巨大的问题。然而，对于许多传染病来说，已经有可能将它们逼至灭绝边缘，而不会出现疫苗逃逸突变体。本文建立了一个理论框架，用以探讨为何会出现这种情况、疫苗的哪些特性促成了这种局面，以及在出现疫苗逃逸突变体的情况下可能会发生什么。
