Longini I M, Halloran M E, Haber M
Division of Biostatistics, Emory University School of Public Health, Atlanta, Georgia.
Math Biosci. 1993 Sep-Oct;117(1-2):271-81. doi: 10.1016/0025-5564(93)90028-9.
A stochastic epidemic model is formulated for the study of the protective effects of vaccination in a population that is stratified by vaccine-related factors. The epidemic model is transformed into a counting process, and then martingale-based methods are used to provide estimators of vaccine efficacy and their variances. Following an example, various extensions of the model are discussed.
建立了一个随机流行病模型，用于研究在按疫苗相关因素分层的人群中疫苗接种的保护效果。将该流行病模型转化为一个计数过程，然后使用基于鞅的方法来提供疫苗效力的估计量及其方差。通过一个例子，讨论了该模型的各种扩展。
