Mira M, Abraham S, McNeil D, Vizzard J, Macaskill P, Fraser I, Llewellyn-Jones D
Department of Obstetrics and Gynaecology, University of Sydney, NSW, Australia.
Psychol Med. 1995 Sep;25(5):947-55. doi: 10.1017/s0033291700037430.
The prospective symptom reports of women seeking treatment for premenstrual symptoms and control subjects was investigated. In order to compare symptom reports from premenstrual symptom sufferers and control subjects a method of combining and analysing prospectively collected menstrual cycle symptom data is required. A technique that uses the time of onset of menses and the time of ovulation (as measured by urinary luteinizing hormone excretion) to standardize each cycle into 14 time points was developed. Summary factors were then empirically derived from data collected prospectively from 30 premenstrual symptom sufferers and 19 control subjects. Twenty-two mood symptoms were summarized into a single factor and the 29 most frequently occurring physical symptoms were summarized into two factors. Factor scores were calculated on the basis of these factors and the effect of time during the menstrual cycle on these scores examined. Both physical symptom factor scores increased significantly in the luteal phase for both the premenstrual symptom sufferer group and the control group. The single mood factor score increased significantly in the luteal phase for the premenstrual sufferer group but not for the control group, suggesting that the only qualitative difference between the groups was the presence of cyclic mood symptoms in the premenstrual symptom sufferer group. The premenstrual symptom sufferer group recorded significantly higher scores on each of the three factors than the control group. The correlation between the scores on each of the factors over three cycles was high both in the follicular and luteal phase suggesting that these factor scores provide a reproducible measure of menstrual cycle symptomatology.
对寻求经前症状治疗的女性和对照受试者的前瞻性症状报告进行了调查。为了比较经前症状患者和对照受试者的症状报告，需要一种合并和分析前瞻性收集的月经周期症状数据的方法。开发了一种利用月经开始时间和排卵时间（通过尿促黄体生成素排泄测量）将每个周期标准化为14个时间点的技术。然后从30名经前症状患者和19名对照受试者前瞻性收集的数据中凭经验得出汇总因素。22种情绪症状被汇总为一个因素，29种最常出现的身体症状被汇总为两个因素。根据这些因素计算因素得分，并检查月经周期中的时间对这些得分的影响。经前症状患者组和对照组的身体症状因素得分在黄体期均显著增加。经前患者组的单一情绪因素得分在黄体期显著增加，而对照组则没有，这表明两组之间唯一的定性差异是经前症状患者组存在周期性情绪症状。经前症状患者组在这三个因素上的得分均显著高于对照组。在卵泡期和黄体期，三个周期中每个因素得分之间的相关性都很高，这表明这些因素得分提供了一种可重复测量月经周期症状的方法。
