Cobb S P, Watson E D
University of Edinburgh, Royal (Dick) School of Veterinary Studies, Easter Bush, Roslin, Midlothian.
Res Vet Sci. 1995 Nov;59(3):238-41. doi: 10.1016/0034-5288(95)90010-1.
Normal uteri were collected from 34 maiden heifers at slaughter and their stage of the oestrous cycle was determined from the ovarian structures. Cells expressing major histocompatibility complex (MHC) class II were widely distributed in the epithelium and lamina propria of the endometrium and were the most abundant population studied. The expression of MHC class II increased in the endometrium during the follicular phase of the cycle. Macrophages occurred throughout the stratum compactum and stratum spongiosum and their density did not appear to vary with the stage of the cycle. CD4+ cells were found mainly in the stratum spongiosum, whereas CD8+ cells were present mainly within the luminal and glandular epithelia and in the stratum compactum. The density of the populations of CD4+ and CD8+ cells increased markedly during the mid-to-late luteal and follicular phases, respectively, of the cycle. In the endometrium lymphoid aggregates were observed only rarely and no B cells were identified in any of the heifers.
从34头屠宰的未孕小母牛收集正常子宫，并根据卵巢结构确定其发情周期阶段。表达主要组织相容性复合体（MHC）II类的细胞广泛分布于子宫内膜的上皮和固有层，且是所研究细胞中数量最多的群体。在发情周期的卵泡期，子宫内膜中MHC II类的表达增加。巨噬细胞遍布致密层和海绵层，其密度似乎不随发情周期阶段而变化。CD4+细胞主要存在于海绵层，而CD8+细胞主要存在于管腔和腺上皮以及致密层。在发情周期的黄体中期到后期，CD4+和CD8+细胞群体的密度分别显著增加。在子宫内膜中仅很少观察到淋巴样聚集物，且在任何一头小母牛中均未鉴定出B细胞。
