Roy M, Schmidt B
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
Semin Thromb Hemost. 1995;21(3):313-6. doi: 10.1055/s-2007-1000652.
Although neonatal thrombosis may be fatal or cause serious morbidity in survivors, strong clinical recommendations on the management of affected infants could not be made in the 1980s because of the lack of sound data from high-quality studies. To determine whether the "right" studies are now being done, a Medline search (exp infant, newborn, and exp thrombosis) for English language articles 1991-1994, was done and 135 citations were found. After exclusion of 59 nonrelevant articles (such as thrombosis in pregnant women or in vitro studies), plus nine letters to the editor, two reviews, and one consensus report, 64 original articles remained. Eighty-four percent of those (54 citations) were case reports and small case series. Experimental designs (prospective or retrospective cohort and case-control studies) were used in only 10 reports. The recently published literature on neonatal thrombosis continues to show an overabundance of anecdotal reports and a shortage of well-designed collaborative studies. The latter are sorely needed to improve the management of affected infants.
尽管新生儿血栓形成可能是致命的，或导致存活者出现严重的发病情况，但在20世纪80年代，由于缺乏高质量研究的可靠数据，无法就受影响婴儿的治疗提出强有力的临床建议。为了确定现在是否正在开展“正确”的研究，我们对1991年至1994年的英文文章进行了Medline检索（检索词为：婴儿、新生儿、血栓形成），共找到135条引用文献。在排除59篇不相关的文章（如孕妇血栓形成或体外研究），以及9篇给编辑的信、2篇综述和1份共识报告后，还剩下64篇原创文章。其中84%（54条引用文献）是病例报告和小病例系列。仅10篇报告采用了实验设计（前瞻性或回顾性队列研究以及病例对照研究）。最近发表的关于新生儿血栓形成的文献仍然显示，轶事报告过多，而精心设计的协作研究不足。迫切需要后者来改善受影响婴儿的治疗。
