Massoco C O, Silva M R, Gorniak S L, Spinosa M S, Bernardi M M
Faculty of Veterinary Medicine, Health Sciences Institute, Paulista University, Brazil.
Vet Hum Toxicol. 1995 Dec;37(6):530-3.
Catnip or catmint (Nepeta cataria) is a plant used extensively to treat human diseases and in toys for pets. We investigated the effects of acute and long-term administration of the plant on some behaviors of mice. The plant was fed as 10% of the normal diet for 2 h/d for 1 or 7 d. Acute and long-term dosing increased both rearing and locomotion frequencies observed in an open field. Acute exposure to catnip increased stereotyped behavior and susceptibility to seizures, did not interfere with haloperidol-induced catalepsy, and decreased sleeping time after sodium pentobarbital administration. Long-term exposure induced tolerance to stereotypic behavior, catalepsy and sleeping time, and increased the susceptibility to seizures induced by picrotoxin and strychnine. An amphetamine-like effect of catnip was suggested to explain the acute effects, while dispositional and functional adaptative changes were considered involved with the long-term effects.
猫薄荷（荆芥）是一种广泛用于治疗人类疾病和制作宠物玩具的植物。我们研究了急性和长期给予该植物对小鼠某些行为的影响。将该植物以正常饮食的10%的比例喂食，每天2小时，持续1天或7天。急性和长期给药均增加了在旷场试验中观察到的竖毛和运动频率。急性接触猫薄荷会增加刻板行为和癫痫易感性，不影响氟哌啶醇诱导的僵住症，且会减少戊巴比妥钠给药后的睡眠时间。长期接触会诱导对刻板行为、僵住症和睡眠时间的耐受性，并增加对印防己毒素和士的宁诱导的癫痫的易感性。猫薄荷类似苯丙胺的作用被认为可以解释急性效应，而代谢和功能适应性变化被认为与长期效应有关。
