Micco A G, Kraus N, Koch D B, McGee T J, Carrell T D, Sharma A, Nicol T, Wiet R J
Department of Otolaryngology, University of Nebraska, Lincoln, USA.
Am J Otol. 1995 Jul;16(4):514-20.
The cognitive P300 evoked potential was elicited by speech stimuli in successful cochlear implant recipients, and the resulting P300 morphology was remarkably similar to that of normal-hearing individuals. The P300 was elicited by the synthesized speech pair/da/and/di/ presented using an oddball paradigm to nine "good" Nucleus cochlear implant users and nine age-matched normal-hearing subjects (34-81 yr old). There were no significant differences in P300 amplitude and latency between the two groups. Moreover, the N1 and P2 potentials occurred at similar latencies in the two groups, although the N1 amplitude was significantly smaller in the cochlear implant users. The P300 was absent in one "poor" cochlear implant user. The results suggest that the P300 may serve as a useful tool for evaluating the cognitive aspects of auditory processing in cochlear implant recipients, and that it may aid in assessing the success of cochlear implantation.
成功植入人工耳蜗的受试者在言语刺激下可引出认知P300诱发电位，其P300形态与听力正常者极为相似。采用oddball范式，向9名“效果良好”的Nucleus人工耳蜗使用者和9名年龄匹配的听力正常受试者（34 - 81岁）呈现合成语音对/da/和/di/，引出P300。两组间P300波幅和潜伏期无显著差异。此外，两组N1和P2电位潜伏期相似，不过人工耳蜗使用者的N1波幅明显较小。一名“效果不佳”的人工耳蜗使用者未引出P300。结果表明，P300可能是评估人工耳蜗植入者听觉处理认知方面的有用工具，且有助于评估人工耳蜗植入的成功与否。
