Wiechert W, Joksch B, Wittig R, Hartbrich A, Höner T, Möllney M
Institut für Biotechnologie, Forschungszentrum Jülich, Germany.
Comput Appl Biosci. 1995 Oct;11(5):517-34. doi: 10.1093/bioinformatics/11.5.517.
The development of software systems for the biosciences is always closely connected to experimental practice. Programs must be able to handle the inherent complexity and heterogeneous structure of biological systems in combination with the measuring equipment. Moreover, a high degree of flexibility is required to treat rapidly changing experimental conditions. Object-oriented methodology seems to be well suited for this purpose. It enables an evolutionary approach to software development that still maintains a high degree of modularity. This paper presents experience with object-oriented technology gathered during several years of programming in the fields of bioprocess development and metabolic engineering. It concentrates on the aspects of experimental support, data analysis, interaction and visualization. Several examples are presented and discussed in the general context of the experimental cycle of knowledge acquisition, thus pointing out the benefits and problems of object-oriented technology in the specific application field of the biosciences. Finally, some strategies for future development are described.
生物科学软件系统的开发始终与实验实践紧密相连。程序必须能够结合测量设备来处理生物系统固有的复杂性和异构结构。此外,还需要高度的灵活性来应对快速变化的实验条件。面向对象方法似乎非常适合这一目的。它支持一种软件开发的演进方法,同时仍保持高度的模块化。本文介绍了在生物过程开发和代谢工程领域多年编程过程中积累的面向对象技术经验。它集中在实验支持、数据分析、交互和可视化方面。给出了几个例子,并在知识获取实验周期的一般背景下进行了讨论,从而指出了面向对象技术在生物科学特定应用领域的优点和问题。最后,描述了一些未来发展的策略。