Schachter J, Dawson C R
Lancet. 1979 Mar 31;1(8118):702-3. doi: 10.1016/s0140-6736(79)91151-6.
In industrialised countries, inclusion conjunctivitis of the newborn is now known to be just one manifestation of a more generalised infection with Chlamydia trachomatis. Pneumonia and enteric infection can develop in perinatally infected infants. It is possible that trachoma in developing countries may reflect extraocular infection that may contribute to the high frequency of pneumonia and diarrhoea in infants in these countries. If true, this would explain the short-term effects of topical treatment, since children could reinfect their eyes by autoinoculation from other sites. Thus systemic treatment with macrolides would result in benefits beyond the temporary suppression of eye disease.
在工业化国家，现在已知新生儿包涵体结膜炎只是沙眼衣原体更广泛感染的一种表现。围产期感染的婴儿可能会发生肺炎和肠道感染。发展中国家的沙眼可能反映了眼外感染，这可能是这些国家婴儿肺炎和腹泻高发的原因之一。如果这是真的，这将解释局部治疗的短期效果，因为儿童可能会通过其他部位的自体接种再次感染眼睛。因此，使用大环内酯类药物进行全身治疗将带来超出暂时抑制眼部疾病的益处。
