一个用于存储由多个细菌和哺乳动物基因突变诱导产生的DNA序列变化的通用数据库。
A general database for DNA sequence changes induced by mutagenesis of several bacterial and mammalian genes.
作者信息
Hutchinson F, Donnellan J E
机构信息
Department of Therapeutic Radiology, Yale University School of Medicine, New Have, CT 06520-8040, USA.
出版信息
Nucleic Acids Res. 1996 Jan 1;24(1):172-6. doi: 10.1093/nar/24.1.172.
This electronic database is a collection of 225 sets of data on mutations in more than twenty-three thousand mutants (October, 1995) in eleven bacterial genes, five mammalian genes and one gene in yeast cells. Each dataset consists of the changes in DNA sequence in the mutants, typically tens to hundreds, induced by mutagenesis of a particular cell line under specific conditions. The database is available on the Internet and on diskettes, and is periodically updated. Researchers are invited to submit additional data. A data entry program, MUTSIN, is available that diagrams each mutation on the computer screen as entered and alerts the user to any inconsistency between the entry and the wild type gene sequence.
这个电子数据库收集了超过两万三千个突变体（1995年10月）在11个细菌基因、5个哺乳动物基因和酵母细胞中的1个基因里的225组突变数据。每个数据集包含在特定条件下对特定细胞系进行诱变所诱导产生的突变体中DNA序列的变化，通常有数十到数百个变化。该数据库可通过互联网获取，也有软盘版本，并且会定期更新。欢迎研究人员提交更多数据。有一个数据录入程序MUTSIN，它能在输入时在电脑屏幕上绘出每个突变的示意图，并提醒用户输入内容与野生型基因序列之间的任何不一致之处。
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