Hutchinson F, Donnellan J E
Radiobiology Laboratory, Department of Therapeutic Radiology and Department of Molecular Biophysics and Biochemistry, Yale University, 333 Cedar Street, New Haven, CT 06520-8040, USA.
Nucleic Acids Res. 1997 Jan 1;25(1):192-5. doi: 10.1093/nar/25.1.192.
Each mutation spectrum in this database is a dataset of changes in DNA base sequence in mutations induced in a gene by a particular mutagen (including spontaneous processes) under defined conditions. There are 240 datasets with 24 500 mutants in nine bacterial genes, two phage genes, five mammalian genes and one yeast gene. The database is available on the Web at http://info.med.yale.edu/mutbase/ . The data tables can be viewed on the Web and downloaded in text form for local use. The data are also available in dBASE III, a format which can be utilized by essentially any desktop computer database program or spreadsheet, and makes feasible analyses of a large number of mutants. Researchers are invited to submit additional data. A data entry program, MUTSIN, diagrams each mutation on the computer screen as the data are entered and alerts the user to any discrepancies between the entry and the gene sequence.
该数据库中的每个突变谱都是在特定条件下由特定诱变剂(包括自发过程)诱导某一基因发生的DNA碱基序列变化的数据集。它包含240个数据集,涉及9个细菌基因、2个噬菌体基因、5个哺乳动物基因和1个酵母基因中的24500个突变体。该数据库可通过网址http://info.med.yale.edu/mutbase/ 在网上获取。数据表可在网上查看,并能以文本形式下载供本地使用。数据也可采用dBASE III格式获取,这种格式基本上可被任何桌面计算机数据库程序或电子表格软件使用,从而便于对大量突变体进行分析。欢迎研究人员提交更多数据。一个名为MUTSIN的数据录入程序,在输入数据时可在计算机屏幕上绘出每个突变的图谱,并提醒用户注意输入内容与基因序列之间的任何差异。