Ma J K, Hein M B
Division of Immunology, UMDS Guy's, London, UK.
Trends Biotechnol. 1995 Dec;13(12):522-7. doi: 10.1016/S0167-7799(00)89016-2.
Plants are capable of synthesizing and assembling virtually every kind of antibody molecule, ranging from the smallest antigen-binding domains and fragments, to full-length, and even multimeric, antibodies. A number of plant hosts can be used, and because this is a versatile expression system that can be scaled-up to agricultural proportions, a cheap and plentiful supply of antibodies could be made available. Immunotherapy is one of the many potential uses for bulk quantities of antibody. In particular, passive immunotherapy of mucosal surfaces may be possible, because functional secretory antibodies can be engineered in plants.
植物能够合成并组装几乎每一种抗体分子，从最小的抗原结合结构域和片段到全长甚至多聚体抗体。可以使用多种植物宿主，并且由于这是一种通用的表达系统，能够扩大到农业规模，因此可以提供廉价且大量的抗体供应。免疫疗法是大量抗体的众多潜在用途之一。特别是，黏膜表面的被动免疫疗法可能可行，因为功能性分泌抗体可以在植物中进行工程改造。
