重组抗体的产生
Generation of recombinant antibodies.
作者信息
Kipriyanov S M, Little M
机构信息
Recombinant Antibody Research Group, German Cancer Research Center, Heidelberg, Germany.
出版信息
Mol Biotechnol. 1999 Sep;12(2):173-201. doi: 10.1385/MB:12:2:173.
PMID:10596374
Abstract
Recombinant antibody technology is opening new perspectives for the development of novel therapeutic and diagnostic agents. In this review we focus on advances in the generation of both genetically engineered humanized and fully human monoclonal antibodies. Methods for their production in different expression systems are also discussed.
摘要
重组抗体技术为新型治疗和诊断试剂的开发开辟了新的前景。在本综述中，我们重点关注基因工程人源化和全人源单克隆抗体生成方面的进展。还讨论了在不同表达系统中生产它们的方法。
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