Boki K A, Kurki P, Holthofer H, Tzioufas A G, Drosos A A, Moutsopoulos H M
Department of Pathophysiology, Medical School, National University of Athens, Greece.
J Rheumatol. 1995 Nov;22(11):2046-8.
The presence of antikeratin antibodies (AKA) has been associated with rheumatoid arthritis (RA) in patients from north and central Europe. Our aim was to investigate the prevalence of AKA in Greek patients with RA.
One hundred and twenty two sera of Greek patients with RA were tested for the presence of AKA by an indirect immunofluorescence technique, and HLA-DR typing was performed by restriction fragment length polymorphism.
Nineteen of 122 (16%) Greek patients with RA were positive for AKA. The percentage of AKA in Greek patients with RA is lower than described previously. These antibodies correlated with a male preponderance (p < 0.01) and were associated with the presence of rheumatoid factor (RF) (p < 0.05) and with HLA-DR1 antigen (p < 0.05).
Our results suggest that AKA are present frequently in Greek patients with RA. Their presence was found to be associated with RF and HLA-DR1 antigen. This emphasizes the different clinical expression of RA in Greece.
在北欧和中欧患者中，抗角蛋白抗体（AKA）的存在与类风湿关节炎（RA）相关。我们的目的是调查希腊RA患者中AKA的患病率。
采用间接免疫荧光技术检测122例希腊RA患者血清中AKA的存在情况，通过限制性片段长度多态性进行HLA - DR分型。
122例希腊RA患者中有19例（16%）AKA呈阳性。希腊RA患者中AKA的百分比低于先前报道。这些抗体与男性占优势相关（p < 0.01），并与类风湿因子（RF）的存在相关（p < 0.05）以及与HLA - DR1抗原相关（p < 0.05）。
我们的结果表明，AKA在希腊RA患者中频繁出现。发现它们的存在与RF和HLA - DR1抗原相关。这强调了RA在希腊的不同临床表型。
