Kessel A, Rosner I, Zuckerman E, Golan T D, Toubi E
Division of Clinical Immunology and Allergy, Bnai Zion Medical Center and Faculty of Medicine, Technion, Haifa, Israel.
J Rheumatol. 2000 Mar;27(3):610-2.
To investigate whether antikeratin antibodies (AKA) could be useful in the differential diagnosis of patients with rheumatoid arthritis (RA) compared to patients with hepatitis C virus (HCV) associated polyarthritis, who are seropositive for rheumatoid factor (RF).
AKA were assayed in 3 different groups of patients; all were RF seropositive: Group 1: 25 patients with HCV associated polyarthralgia or arthritis. Group 2: 33 patients with RA. Group 3: 13 patients with autoimmune disorders other than RA. Fifteen healthy individuals served as controls.
AKA were detected in 20/33 patients with RA (60.6%) compared to only 2/25 patients (8%) with HCV associated arthritis (p < 0.0001). AKA were observed in 2/13 patients of Group 3 (15.3%). These results were also statistically different from those of patients with RA (p = 0.008). AKA were not found in the sera of the healthy controls.
AKA is a useful marker to differentiate patients with RA from those with hepatitis C arthritis.
研究抗角蛋白抗体（AKA）对于类风湿关节炎（RA）患者与类风湿因子（RF）血清学阳性的丙型肝炎病毒（HCV）相关性多关节炎患者进行鉴别诊断是否有用。
对3组不同患者检测AKA；所有患者RF血清学均为阳性：第1组：25例HCV相关性多关节痛或关节炎患者。第2组：33例RA患者。第3组：13例除RA外的自身免疫性疾病患者。15名健康个体作为对照。
33例RA患者中有20例（60.6%）检测到AKA，相比之下，25例HCV相关性关节炎患者中仅有2例（8%）检测到AKA（p < 0.0001）。第3组13例患者中有2例（15.3%）检测到AKA。这些结果与RA患者的结果在统计学上也有差异（p = 0.008）。健康对照血清中未发现AKA。
AKA是区分RA患者与丙型肝炎关节炎患者的有用标志物。
