Puttick M P, Klinkhoff A V, Chalmers A, Ostrow D N
Department of Medicine, University of British Columbia, Vancouver, Canada.
J Rheumatol. 1995 Nov;22(11):2163-5.
A 62-year-old man with longstanding rheumatoid arthritis (RA) presented with dyspnea. Active rheumatoid interstitial lung disease was documented by high resolution computed tomography, gallium scan, and bronchoalveolar lavage. He responded to high dose prednisone, but had unacceptable side effects. Chlorambucil and cyclophosphamide were not steroid sparing. After starting cyclosporine 3 mg/kg/day he was able to stop prednisone and his symptoms improved and stabilized. Pulmonary function showed sustained improvement during 2 years of followup. His RA has been well controlled. Side effects have been mild hypertension and increased serum creatinine.
一名患有长期类风湿性关节炎（RA）的62岁男性出现呼吸困难。高分辨率计算机断层扫描、镓扫描和支气管肺泡灌洗证实存在活动性类风湿性间质性肺病。他对高剂量泼尼松有反应，但出现了无法接受的副作用。苯丁酸氮芥和环磷酰胺不能减少类固醇用量。开始使用环孢素3毫克/千克/天后，他能够停用泼尼松，症状得到改善并稳定下来。在2年的随访期间，肺功能持续改善。他的类风湿性关节炎得到了很好的控制。副作用为轻度高血压和血清肌酐升高。
