Yunt Zulma X, Solomon Joshua J
Autoimmune Lung Center, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA.
Autoimmune Lung Center, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA.
Rheum Dis Clin North Am. 2015 May;41(2):225-36. doi: 10.1016/j.rdc.2014.12.004. Epub 2015 Feb 3.
Rheumatoid arthritis (RA) affects approximately 1% of the US population frequently has extra-articular manifestations. Most compartments of the lung are susceptible to disease. Interstitial lung disease (ILD) and airways disease are the most common forms of RA-related lung disease. RA-ILD carries the worst prognosis and most often manifests in a histologic pattern of usual interstitial pneumonia or nonspecific interstitial pneumonia. There have been no large, well-controlled prospective studies investigating therapies for RA-ILD. Treatment usually entails immunomodulatory agents. Further studies are needed to better understand pathogenic mechanisms of disease that lead to lung involvement in these patients.
类风湿性关节炎（RA）影响着约1%的美国人口，常伴有关节外表现。肺部的大多数区域都易患此病。间质性肺疾病（ILD）和气道疾病是类风湿性关节炎相关肺部疾病最常见的形式。类风湿性关节炎相关间质性肺疾病预后最差，最常表现为普通型间质性肺炎或非特异性间质性肺炎的组织学模式。目前尚无大型、严格对照的前瞻性研究来调查类风湿性关节炎相关间质性肺疾病的治疗方法。治疗通常需要使用免疫调节剂。需要进一步研究以更好地了解导致这些患者肺部受累的疾病致病机制。
