Callander R D, Mackay J M, Clay P, Elcombe C R, Elliott B M
ZENECA Central Toxicology Laboratory, Macclesfield, Cheshire, UK.
Mutagenesis. 1995 Nov;10(6):517-22. doi: 10.1093/mutage/10.6.517.
A series of bacterial mutation, mammalian cell (L5178Y) gene mutation and in vitro cytogenetic assays were performed to compare the efficacy of using S9 fractions prepared from rats induced with a combination of phenobarbital (PB) and beta-naphthoflavone (beta NF), with S9 fractions from rats treated with the general enzyme inducer Aroclor 1254. Although some quantitative differences in the magnitudes of the mutagenic/clastogenic effects were observed between the two induction regimes, no qualitative differences were observed. The use of a combined PB/beta NF induction regime using oral dosing is therefore considered to be a suitable substitute for Aroclor 1254.
进行了一系列细菌突变、哺乳动物细胞（L5178Y）基因突变和体外细胞遗传学试验，以比较用苯巴比妥（PB）和β-萘黄酮（βNF）联合诱导的大鼠制备的S9组分与用通用酶诱导剂多氯联苯混合物1254处理的大鼠的S9组分的效果。尽管在两种诱导方案之间观察到诱变/致断裂效应的大小存在一些定量差异，但未观察到定性差异。因此，使用口服给药的PB/βNF联合诱导方案被认为是多氯联苯混合物1254的合适替代品。
