Elliott B M, Combes R D, Elcombe C R, Gatehouse D G, Gibson G G, Mackay J M, Wolf R C
ICI Central Toxicology Laboratory, Macclesfield, UK.
Mutagenesis. 1992 May;7(3):175-7. doi: 10.1093/mutage/7.3.175.
A working party was set up by the UK Environmental Mutagen Society to consider alternatives to Aroclor 1254 (Aroclor)-induced S9 in in vitro genotoxicity assays, with the aims of considering whether a replacement for Aroclor in its role in general screening assays could be readily identified. The working party concluded that there was sufficient support in the literature to justify the use of an appropriate phenobarbital/beta-naphthoflavone regime as an acceptable alternative to Aroclor.
英国环境诱变剂学会成立了一个工作小组，以探讨在体外遗传毒性试验中替代用Aroclor 1254（多氯联苯混合物）诱导产生S9的方法，目的是考虑是否能轻易找到一种可替代Aroclor用于一般筛选试验的物质。该工作小组得出结论，文献中有足够的支持依据，证明使用适当的苯巴比妥/β-萘黄酮方案作为Aroclor的可接受替代物是合理的。
