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Prostaglandin and thromboxane biosynthesis inhibitors.

作者信息

Gryglewski R J

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1977;297 Suppl 1:S85-8. doi: 10.1007/BF00587789.

DOI:10.1007/BF00587789
PMID:859658
Abstract

All acidic non-steroidal anti-inflammatory drugs suppress the activity of microsomal cyclo-oxygenase of arachidonic acid; therefore, these drugs are equipotent inhibitors of prostaglandin and thromboxane generation. A non-acidic anti-inflammatory agent, 1'-(isopropyl-2-indolyl)-3-pyridyl-3-ketone (L 8027), selectively inhibits biosynthesis of thromboxane A2 in blood platelets and in lungs.

摘要

相似文献

1
Prostaglandin and thromboxane biosynthesis inhibitors.
Naunyn Schmiedebergs Arch Pharmacol. 1977;297 Suppl 1:S85-8. doi: 10.1007/BF00587789.
2
Synthesis of thromboxane A2 by non-aggregating dog platelets challenged with arachidonic acid or with prostaglandin H2.用花生四烯酸或前列腺素H2刺激非聚集性犬血小板合成血栓素A2 。
Prostaglandins. 1977 Aug;14(2):222-40. doi: 10.1016/0090-6980(77)90168-x.
3
On the formation and effects of thromboxane A2 in human platelets.关于血栓素A2在人血小板中的形成及其作用
Acta Physiol Scand. 1976 Nov;98(3):285-94. doi: 10.1111/j.1748-1716.1976.tb10313.x.
4
Selective inhibition of thromboxane A2 biosynthesis in blood platelets.血液血小板中血栓素A2生物合成的选择性抑制。
Nature. 1977 Jun 16;267(5612):627-8. doi: 10.1038/267627a0.
5
A potent inhibitor of thromboxane A2 biosynthesis in aggregating human blood platelets.在人血小板聚集过程中对血栓素A2生物合成有强效抑制作用的物质。
Pharmacol Res Commun. 1977 Feb;9(2):109-16. doi: 10.1016/s0031-6989(77)80013-1.
6
Selective inhibitory actions of sodium-p-benzyl-4-[1-oxo-2-(4-chlorobenzyl)-3-phenyl propyl] phenyl phosphonate (N-0161) and indomethacin on the biosynthesis of prostaglandins and thromboxanes from arachidonic acid.对苄基-4-[1-氧代-2-(4-氯苄基)-3-苯基丙基]苯基膦酸钠（N-0161）和吲哚美辛对花生四烯酸生物合成前列腺素和血栓烷的选择性抑制作用。
Br J Pharmacol. 1977 May;60(1):135-40. doi: 10.1111/j.1476-5381.1977.tb16757.x.
7
Solubilization and resolution of thromboxane synthesizing system from microsomes of bovine blood platelets.牛血小板微粒体中血栓素合成系统的增溶与解析
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8
[The prostaglandin-thromboxan system].[前列腺素-血栓素系统]
Schweiz Med Wochenschr. 1977 Jun 4;107(22):753-6.
9
Diversion of prostaglandin endoperoxide metabolism by selective inhibition of thromboxane A2 biosynthesis in lung, spleen or platelets.通过选择性抑制肺、脾或血小板中血栓素A2的生物合成来改变前列腺素内过氧化物代谢。
Eur J Pharmacol. 1977 Jul 15;44(2):179-86. doi: 10.1016/0014-2999(77)90104-2.
10
N-0164 inhibits generation of thromboxane-A2-like activity from prostaglandin endoperoxides by human platelet microsomes.N-0164可抑制人血小板微粒体由前列腺素内过氧化物生成血栓素A2样活性。
Prostaglandins. 1976 Sep;12(3):465-9. doi: 10.1016/0090-6980(76)90027-7.

引用本文的文献

1
The metabolism of arachidonic acid in the isolated tracheal and lung strip preparations of guinea-pigs.豚鼠离体气管和肺条制备物中花生四烯酸的代谢
Lung. 1980;158(3):121-9. doi: 10.1007/BF02713714.
2
Mechanisms of coronary vasoconstriction induced by Na arachidonate in experimentally diabetic dogs.
Experientia. 1982 Jul 15;38(7):835-7. doi: 10.1007/BF01972301.
3
Arachidonic acid-induced platelet aggregation and prostanoid formation in whole blood in relation to plasma concentration of indomethacin.花生四烯酸诱导的全血中血小板聚集和类前列腺素生成与血浆中吲哚美辛浓度的关系

本文引用的文献

1
THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOOD.利用离体器官检测循环血液中的活性物质
Br J Pharmacol Chemother. 1964 Oct;23(2):360-73. doi: 10.1111/j.1476-5381.1964.tb01592.x.
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Prostaglandins released by the spleen.脾脏释放的前列腺素。
Nature. 1968 Jun 22;218(5147):1135-40. doi: 10.1038/2181135a0.
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[In vitro inhibition of the biosynthesis of E 2 prostaglandin by anti-inflammatory drugs].[抗炎药物对E2前列腺素生物合成的体外抑制作用]
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In vivo method for quantitation for anti-platelet potency of drugs.
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Hyperthermic effects of arachidonic acid, prostaglandin E2 and F2alpha in rats.花生四烯酸、前列腺素E2和F2α对大鼠的热效应
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Inhibition of human platelet aggregation by oral administration of nicergoline. A double-blind study.口服尼麦角林对人血小板聚集的抑制作用。一项双盲研究。
Farmaco Prat. 1975 Dec;30(12):630-40.
5
Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.血栓素：一类从前列腺素内过氧化物衍生而来的新型生物活性化合物。
Proc Natl Acad Sci U S A. 1975 Aug;72(8):2994-8. doi: 10.1073/pnas.72.8.2994.
6
The effects of prostagladin endoperoxides and thromboxane A2 on strips of rabbit coeliac artery and certain other smooth muscle preparations [proceedings].前列腺素内过氧化物和血栓素A2对兔腹腔动脉条及某些其他平滑肌制剂的作用[会议论文集]
Br J Pharmacol. 1976 Jul;57(3):462P-463P.
7
Thromboxanes: selective biosynthesis and distinct biological properties.血栓烷：选择性生物合成与独特生物学特性
Science. 1976 Jul 9;193(4248):163-5. doi: 10.1126/science.945611.
8
Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides.在血小板微粒体中鉴定出一种可将前列腺素内过氧化物转化为血栓素A2的酶。
Nature. 1976 Jun 17;261(5561):558-60. doi: 10.1038/261558a0.
9
The influence of saturated fatty acids on prostaglandin synthetase activity.饱和脂肪酸对前列腺素合成酶活性的影响。
Biochem Pharmacol. 1975 Nov 15;24(22):2057-60. doi: 10.1016/0006-2952(75)90102-1.