肿瘤中的巨大桥粒
Giant desmosomes in tumors.
作者信息
Ghadially F N, Rippstein P U, Cavell S, Venance S L
机构信息
Department of Laboratory Medicine, Ottawa Civic Hospital, Ontario, Canada.
出版信息
Ultrastruct Pathol. 1995 Nov-Dec;19(6):469-74. doi: 10.3109/01913129509014621.
The lengths of desmosomal profiles were measured in sections of tumor tissue from cases of mesothelioma, adenocarcinoma, squamous cell carcinoma, thymoma, and meningioma. Giant desmosomes (length of profile 1 micron or greater than 1 micron) were found in all the above-mentioned tumors except adenocarcinomas. The largest desmosomal profile in adenocarcinoma was approximately 0.8 micron long; the largest in mesothelioma was approximately 2 microns long. Our observations suggest that one of the ways in which giant desmosomes arise is by growth and fusion of adjacent desmosomes. Giant desmosomes may at times help in distinguishing mesothelioma from adenocarcinoma, but this is a rather rare phenomenon. In this study giant desmosomes were found in only 2 out of 10 cases of mesothelioma.
在间皮瘤、腺癌、鳞状细胞癌、胸腺瘤和脑膜瘤病例的肿瘤组织切片中测量了桥粒轮廓的长度。除腺癌外，在上述所有肿瘤中均发现了巨大桥粒（轮廓长度为1微米或大于1微米）。腺癌中最大的桥粒轮廓约0.8微米长；间皮瘤中最大的约2微米长。我们的观察结果表明，巨大桥粒出现的方式之一是相邻桥粒的生长和融合。巨大桥粒有时可能有助于将间皮瘤与腺癌区分开来，但这是一种相当罕见的现象。在本研究中，10例间皮瘤病例中仅2例发现了巨大桥粒。
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