Paxton W A, Martin S R, Tse D, O'Brien T R, Skurnick J, VanDevanter N L, Padian N, Braun J F, Kotler D P, Wolinsky S M, Koup R A
Aaron Diamond AIDS Research Center, New York, New York 10016, USA.
Nat Med. 1996 Apr;2(4):412-7. doi: 10.1038/nm0496-412.
Some individuals remain uninfected with human immunodeficiency virus type-1 (HIV-1) despite multiple high-risk sexual exposures. We studied a cohort of 25 subjects with histories of multiple high-risk sexual exposures to HIV-1 and found that their CD8+ lymphocytes had greater anti-HIV-1 activity than did CD8+ lymphocytes from nonexposed controls. Further studies indicated that their purified CD4+ lymphocytes were less susceptible to infection with multiple primary isolates of HIV-1 than were CD4+ lymphocytes from the nonexposed controls. This relative resistance to HIV-1 infection did not extend to T-cell line-adapted strains, was restricted by the envelope glycoprotein, was not explained by the cell surface density of CD4 molecules, but was associated with the activity of the C-C chemokines RANTES, MIP-1alpha, and MIP-1beta. This relative resistance of CD4+ lymphocytes may contribute to protection from HIV-1 in multiply exposed persons.
尽管有多次高危性接触，但一些个体仍未感染1型人类免疫缺陷病毒（HIV-1）。我们研究了一组有多次HIV-1高危性接触史的25名受试者，发现他们的CD8 +淋巴细胞比未接触过HIV-1的对照者的CD8 +淋巴细胞具有更强的抗HIV-1活性。进一步研究表明，与未接触过HIV-1的对照者的CD4 +淋巴细胞相比，他们纯化的CD4 +淋巴细胞对多种HIV-1原始分离株的感染更不易感。这种对HIV-1感染的相对抗性并不适用于适应T细胞系的毒株，受包膜糖蛋白的限制，不能用CD4分子的细胞表面密度来解释，但与C-C趋化因子RANTES、MIP-1α和MIP-1β的活性有关。CD4 +淋巴细胞的这种相对抗性可能有助于多次接触HIV-1的人免受感染。
