Rocha M O, Rocha R L, Pedroso E R, Greco D B, Ferreira C S, Lambertucci J R, Katz N, Rocha R S, Rezende D F, Neves J
Medical School, Federal University of Minas Gerais, Belo Horizonte, Brasil.
Rev Inst Med Trop Sao Paulo. 1995 Jul-Aug;37(4):311-8. doi: 10.1590/s0036-46651995000400005.
The clinical and radiological pulmonary manifestations in the initial phase of schistosomiasis mansoni were studied in thirty previously healthy individuals who were simultaneously infected. The findings were compared with those concerning a control group and related to possible pathogenetic factors. The respiratory manifestations were of light or of moderate intensity, the dry cough being the most common symptom. The significant radiological alterations were: thickening of bronchial walls and beaded micronodulation, predominantly localized in the lower pulmonary fields. It was observed significant association between wheezing and IgE levels, estimated by the area of immediate intradermal reaction, as well as between the number of blood eosinophils and the occurrence of radiological changes. Moreover, there was correlation between the worm burden and the presence of wheezing, thoracic pain and beaded micronodulation. Thus, the clinical and radiological pulmonary manifestations described are significant part of the initial phase of schistosomiasis mansoni and present the worm burden, eosinophilia and levels of IgE as probable pathogenetic factors.
对30名同时感染曼氏血吸虫病的既往健康个体，研究了其疾病初期的临床和放射学肺部表现。将研究结果与对照组的结果进行比较，并探讨了可能的发病因素。呼吸系统表现为轻度或中度，干咳是最常见的症状。显著的放射学改变包括：支气管壁增厚和串珠状小结节，主要位于肺下野。观察到喘息与通过皮内速发反应面积估算的IgE水平之间存在显著关联，以及血液嗜酸性粒细胞数量与放射学改变的发生之间存在显著关联。此外，虫负荷与喘息、胸痛和串珠状小结节的存在之间存在相关性。因此，所描述的临床和放射学肺部表现是曼氏血吸虫病初期的重要组成部分，并表明虫负荷、嗜酸性粒细胞增多和IgE水平可能是发病因素。
