Schekman R, Orci L
Department of Molecular and Cell Biology, University of California, Berkeley, 94720-3202, USA.
Science. 1996 Mar 15;271(5255):1526-33. doi: 10.1126/science.271.5255.1526.
The trafficking of proteins within eukaryotic cells is achieved by the capture of cargo and targeting molecules into vesicles that bud from a donor membrane and deliver their contents to a receiving department. This process is bidirectional and may involve multiple organelles within a cell. Distinct coat proteins mediate each budding event, serving both to shape the transport vesicle and to select by direct or indirect interaction the desired set of cargo molecules. Secretion, which has been viewed as a default pathway, may require sorting and packaging signals on transported molecules to ensure their rapid delivery to the cell surface.
真核细胞内蛋白质的运输是通过将货物和靶向分子捕获到小泡中来实现的，这些小泡从供体膜上芽生出来，并将其内容物输送到接收部位。这个过程是双向的，可能涉及细胞内的多个细胞器。不同的衣被蛋白介导每个出芽事件，既用于塑造运输小泡，又通过直接或间接相互作用选择所需的一组货物分子。一直被视为默认途径的分泌过程，可能需要运输分子上的分选和包装信号，以确保它们能迅速输送到细胞表面。
