Frazier J A, Giedd J N, Kaysen D, Albus K, Hamburger S, Alaghband-Rad J, Lenane M C, McKenna K, Breier A, Rapoport J L
Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA.
Am J Psychiatry. 1996 Apr;153(4):564-6. doi: 10.1176/ajp.153.4.564.
The effect of clozapine on striatal morphology was examined in adolescents with childhood-onset schizophrenia.
Eight adolescent patients with onset of psychosis before age 12 and eight matched comparison subjects had initial and 2-year follow-up brain magnetic resonance imaging scans. Basal ganglia and lateral ventricle volumes were measured. The patients were on a clozapine regimen during the 2-year interim.
Caudate volume was larger in the patients at the initial scanning, decreased in the patients between scans, and did not differ significantly between the patients and the comparison subjects at the second scanning.
Caudate enlargement in patients with childhood-onset schizophrenia who are taking typical neuroleptics appears to be secondary to medication exposure. Rescanning to examine basal ganglia morphology is indicated for these patients when they are taking an atypical neuroleptic.
研究氯氮平对儿童期起病的精神分裂症青少年纹状体形态的影响。
8例12岁前起病的青少年精神病患者和8例匹配的对照受试者进行了首次及2年随访脑磁共振成像扫描。测量基底节和侧脑室体积。患者在2年的间期内接受氯氮平治疗方案。
初次扫描时患者的尾状核体积较大，两次扫描之间患者的尾状核体积减小，第二次扫描时患者与对照受试者之间无显著差异。
服用典型抗精神病药物的儿童期起病的精神分裂症患者的尾状核增大似乎继发于药物暴露。这些患者服用非典型抗精神病药物时，建议重新扫描以检查基底节形态。
