Keshavan M S, Rosenberg D, Sweeney J A, Pettegrew J W
Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213-2593, USA. Keshavan+@Pitt.edu
Am J Psychiatry. 1998 Jun;155(6):774-8. doi: 10.1176/ajp.155.6.774.
Previous studies, mostly involving neuroleptic-treated patients, have suggested enlarged basal ganglia size in schizophrenia. The authors sought to examine basal ganglia volume in neuroleptic-naive psychotic patients.
Magnetic resonance imaging volumetric studies were conducted in newly diagnosed neuroleptic-naive schizophrenic and non-schizophrenic psychotic patients and in matched healthy comparison subjects.
Both patient groups had bilaterally reduced caudate, but not putamen, volumes, compared to the healthy subjects, after adjustment for intracranial volume.
Decreases in caudate volume in newly diagnosed psychotic patients may be related to the primary pathophysiology of these disorders; prior observations of increased caudate volume may reflect effects of neuroleptic treatment.
以往研究大多涉及使用抗精神病药物治疗的患者，提示精神分裂症患者基底神经节体积增大。作者试图研究未使用抗精神病药物的精神病患者的基底神经节体积。
对新诊断的未使用抗精神病药物的精神分裂症和非精神分裂症精神病患者以及匹配的健康对照者进行磁共振成像体积研究。
在调整颅内体积后，与健康受试者相比，两组患者的双侧尾状核体积均减小，但壳核体积未减小。
新诊断的精神病患者尾状核体积减小可能与这些疾病的原发性病理生理学有关；先前观察到的尾状核体积增加可能反映了抗精神病药物治疗的效果。
