McCluggage W G, Roberts N, Bharucha H
Department of Histopathology, Royal Group of Hospitals, Belfast, Northern Ireland.
Int J Gynecol Pathol. 1995 Jul;14(3):250-4. doi: 10.1097/00004347-199507000-00009.
A histochemical study revealed focal intracytoplasmic mucin within 50% of a series of adenocarcinomas arising within the endometrium. Seventeen percent of the adenocarcinomas studied contained intracytoplasmic O-acetylated sialomucins, as demonstrated by the PB/KOH/PAS technique. The presence of O-acetylated sialomucin, indicating enteric or intestinal differentiation, has not previously been demonstrated within endometrial adenocarcinomas, although it is well described in endocervical adenocarcinomas and in mucinous tumors of the ovary. In none of the cases in which enteric-type mucins were identified was there morphological evidence of intestinal differentiation in the form of goblet cells or Paneth cells. No correlation was found between the presence of enteric mucins and the grade of the adenocarcinoma. The results of the study provide further confirmation of the ability of the epithelial lining of the female genital tract to undergo various forms of metaplasia, along both Mullerian and non-Mullerian pathways. The demonstration of specific mucins is more sensitive than morphology in establishing enteric differentiation.
一项组织化学研究显示，在一系列子宫内膜腺癌中，50%存在局灶性胞浆内黏液。采用PB/KOH/PAS技术证实，所研究的腺癌中有17%含有胞浆内O-乙酰化涎黏蛋白。O-乙酰化涎黏蛋白的存在表明有肠型或肠化生，此前在子宫内膜腺癌中尚未得到证实，不过在宫颈腺癌和卵巢黏液性肿瘤中已有充分描述。在鉴定出肠型黏液的所有病例中，均未发现杯状细胞或潘氏细胞形式的肠化生形态学证据。未发现肠黏蛋白的存在与腺癌分级之间存在相关性。该研究结果进一步证实了女性生殖道上皮沿着苗勒氏管和非苗勒氏管途径发生各种化生的能力。在确定肠化生方面，特定黏液的显示比形态学更敏感。
