Fox H, Wells M, Harris M, McWilliam L J, Anderson G S
Department of Pathology, University of Manchester, UK.
Histopathology. 1988 Feb;12(2):167-76. doi: 10.1111/j.1365-2559.1988.tb01927.x.
Three enteric-type neoplasms of the lower female genital tract are described; an enteric adenocarcinoma of the cervix, an enteric adenocarcinoma of the vagina and a tubulo-villous adenoma of the vagina. The two adenocarcinomas were characterized by the presence of columnar cells with a prominent brush border and an abundance of goblet cells. The tubulovillous adenoma was identical to similar lesions found in the large intestine. The criteria for diagnosis of an enteric adenocarcinoma of the female genital tract are discussed and it is concluded that the histochemical demonstration of o-acetylated sialomucin is the most specific marker of intestinal differentiation. It is suggested that enteric tumours of the cervix arise from foci of gastrointestinal metaplasia. Enteric tumours of the vagina are more likely to develop from cloacal remnants.
宫颈肠型腺癌、阴道肠型腺癌和阴道管状绒毛状腺瘤。这两种腺癌的特征是存在具有明显刷状缘的柱状细胞和大量杯状细胞。管状绒毛状腺瘤与在大肠中发现的类似病变相同。讨论了女性生殖道肠型腺癌的诊断标准，得出结论：o-乙酰化唾液酸粘蛋白的组织化学证明是肠化生最特异的标志物。提示宫颈的肠型肿瘤起源于胃肠化生灶。阴道的肠型肿瘤更可能由泄殖腔残余发展而来。
