Wong M, Eulenberger J, Schenk R, Hunziker E
M. E. Müller Institute for Biomechanics, University of Bern, Switzerland.
J Biomed Mater Res. 1995 Dec;29(12):1567-75. doi: 10.1002/jbm.820291213.
The importance of surface topology and implant material composition on osseointegration in trabecular bone was investigated using three commericially used implant materials and surface-texturing procedures which included blasting, high temperature acid etching, and hydroxyapatite (HA) coating. Surface roughness and spacing parameters were measured for each implant group with a laser interferometric profilometer. Cylindrical implants were press-fit into trabecular bone sites in the knee of mature miniature pigs. After 12 weeks in situ, osseointegration was evaluated by (1) mechanical pushout tests to measure bone-implant interface strength and (2) quantitative morphometric measurements of the percent implant surface covered by bone. We found that HA-coated implants showed superior osseointegration in terms of both pushout failure load and surface coverage by bone measurements. An excellent correlation (r2 = .90) was found between the average roughness of the implant surface and pushout failure load. New methods for altering the local topologic and/or chemical state of the implant surface (i.e., by acid etching) may provide an important new avenue of research for improving the osseointegrative properties of orthopedic materials.
使用三种商业上常用的植入材料和表面纹理处理程序（包括喷砂、高温酸蚀和羟基磷灰石（HA）涂层），研究了表面拓扑结构和植入材料成分对松质骨骨整合的重要性。使用激光干涉轮廓仪测量每个植入组的表面粗糙度和间距参数。将圆柱形植入物压配合到成熟小型猪膝关节的松质骨部位。原位放置12周后，通过以下方法评估骨整合情况：（1）机械推出试验，以测量骨-植入物界面强度；（2）定量形态测量骨覆盖植入物表面的百分比。我们发现，就推出失败载荷和骨测量的表面覆盖率而言，HA涂层植入物显示出更好的骨整合。在植入物表面的平均粗糙度与推出失败载荷之间发现了极好的相关性（r2 = 0.90）。改变植入物表面局部拓扑和/或化学状态的新方法（即通过酸蚀）可能为改善骨科材料的骨整合性能提供重要的新研究途径。
