Kemeny M E, Weiner H, Duran R, Taylor S E, Visscher B, Fahey J L
Department of Psychiatry and Biobehavioral Sciences, School of Medicine, University of California, Los Angeles 90024, USA.
Psychosom Med. 1995 Nov-Dec;57(6):547-54. doi: 10.1097/00006842-199511000-00007.
The objectives of this study were to determine 1) whether immune changes relevant to HIV progression occurred in HIV-seropositive men after the death of their intimate partner, and 2) whether depressed mood was associated with these immune changes. The bereaved group consisted of 39 gay men whose intimate partners had died of AIDS over the past year; the nonbereaved group consisted of 39 age- and HIV serostatus-matched nonbereaved men. Immunological parameters were assayed from blood samples drawn before and within 1 year after the death of the partner (bereaved group) or over an equivalent time period (nonbereaved group). In the HIV-seropositive bereaved men only, a significant increase in immune activation and a significant decrease in the proliferative response to phytohemagglutinin occurred after the death of the partner. These immunological changes were not explained by the use of recreational drugs, alcohol, cigarettes, or AZT. These data indicate that the death of an intimate partner in HIV-positive men is associated with immune changes that are relevant to HIV progression.
1）HIV血清反应呈阳性的男性在其亲密伴侣去世后是否发生了与HIV病情进展相关的免疫变化；2）情绪低落是否与这些免疫变化相关。丧亲组由39名男同性恋者组成，他们的亲密伴侣在过去一年中死于艾滋病；非丧亲组由39名年龄和HIV血清状态相匹配的未丧亲男性组成。从伴侣去世前及去世后1年内（丧亲组）或同等时间段（非丧亲组）采集的血样中检测免疫参数。仅在HIV血清反应呈阳性的丧亲男性中，伴侣去世后免疫激活显著增加，对植物血凝素的增殖反应显著降低。这些免疫变化无法用使用消遣性药物、酒精、香烟或齐多夫定来解释。这些数据表明，HIV阳性男性的亲密伴侣死亡与和HIV病情进展相关的免疫变化有关。
