O'Connor Mary-Frances
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA, USA.
Dialogues Clin Neurosci. 2012 Jun;14(2):141-8. doi: 10.31887/DCNS.2012.14.2/mfoconnor.
Complicated grief (CG) is a disorder marked by intense and persistent yearning for the deceased, in addition to other criteria. The present article reviews what is known about the immunologic and neuroimaging biomarkers of both acute grief and CG, Attachment theory and cognitive stress theory are reviewed as they pertain to bereavement, as is the biopsychosocial model of CG. Reduced immune cell function has been replicated in a variety of bereaved populations. The regional brain activation to grief cues frequently includes the dorsal anterior cingulate cortex and insula, and also the posterior cingulate cortex. Using theory to point to future research directions, we may eventually learn which biomarkers are helpful in predicting CG, and its treatment.
复杂性悲伤（CG）是一种除其他标准外，以对逝者强烈且持续的思念为特征的障碍。本文回顾了关于急性悲伤和复杂性悲伤的免疫和神经影像学生物标志物的已知情况。依恋理论和认知应激理论在与丧亲相关的方面进行了回顾，复杂性悲伤的生物心理社会模型也同样如此。免疫细胞功能降低在各种丧亲人群中都得到了验证。大脑对悲伤线索的区域激活通常包括背侧前扣带回皮层和脑岛，以及后扣带回皮层。利用理论来指明未来的研究方向，我们最终可能会了解哪些生物标志物有助于预测复杂性悲伤及其治疗方法。
