Skop B P, Brown T M
Department of Psychiatry, Wilford Hall Medical Center, Lackland AFB, TX 78236-5300, USA.
Psychosomatics. 1996 Jan-Feb;37(1):12-6. doi: 10.1016/S0033-3182(96)71592-X.
Selective serotonin reuptake inhibitors (SSRIs) alter peripheral handling of serotonin, leading to potential side effects. Further, the majority of the body's serotonin is found outside the central nervous system. Peripheral serotonin is important in platelet aggregation and the modulation of vascular tone. SSRIs block platelet uptake and pulmonary endothelial metabolism of serotonin, and use of these agents may conceivably result in bleeding and vasospastic complications.
选择性5-羟色胺再摄取抑制剂（SSRI）会改变5-羟色胺的外周处理过程，从而导致潜在的副作用。此外，人体大部分的5-羟色胺存在于中枢神经系统之外。外周5-羟色胺在血小板聚集和血管张力调节中起重要作用。SSRI会阻断血小板对5-羟色胺的摄取以及肺内皮细胞对5-羟色胺的代谢，使用这些药物可能会导致出血和血管痉挛并发症。
