果蝇（6-4）光裂合酶、人类光裂合酶同源物与DNA光裂合酶-蓝光光感受器家族之间的相似性。
Similarity among the Drosophila (6-4)photolyase, a human photolyase homolog, and the DNA photolyase-blue-light photoreceptor family.
作者信息
Todo T, Ryo H, Yamamoto K, Toh H, Inui T, Ayaki H, Nomura T, Ikenaga M
机构信息
Radiation Biology Center, Kyoto University, Kyoto, Japan.
出版信息
Science. 1996 Apr 5;272(5258):109-12. doi: 10.1126/science.272.5258.109.
Ultraviolet light (UV)-induced DNA damage can be repaired by DNA photolyase in a light-dependent manner. Two types of photolyase are known, one specific for cyclobutane pyrimidine dimers (CPD photolyase) and another specific for pyrimidine (6-4) pyrimidone photoproducts[(6-4)photolyase]. In contrast to the CPD photolyase, which has been detected in a wide variety of organisms, the (6-4)photolyase has been found only in Drosophila melanogaster. In the present study a gene encoding the Drosophila(6-4)photolyase ws cloned, and the deduced amino acid sequence of the product was found to be similar to the CPD photolyase and to the blue-light photoreceptor of plants. A homolog of the Drosophila (6-4)photolyase gene was also cloned from human cells.
紫外线（UV）诱导的DNA损伤可由DNA光解酶以光依赖的方式修复。已知有两种类型的光解酶，一种对环丁烷嘧啶二聚体具有特异性（CPD光解酶），另一种对嘧啶（6-4）嘧啶酮光产物具有特异性[（6-4）光解酶]。与已在多种生物体中检测到的CPD光解酶不同，（6-4）光解酶仅在黑腹果蝇中发现。在本研究中，克隆了编码果蝇（6-4）光解酶的基因，发现其推导的氨基酸序列与CPD光解酶以及植物的蓝光光感受器相似。还从人细胞中克隆了果蝇（6-4）光解酶基因的同源物。
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