[The effect of thyroid hormones, phorbol esters, and sphingosine on incorporation of linoleic acid in liver lipids of white rats].

The effects of thyroxine, phorbol esters and sphingosine on incorporation of [14C]linoleic acid into phospholipids, triacylglycerols and cholesterol esters of albino rat liver have been studied. It has been found that phorbol-12-myristate-13-acetate and thyroxine activate the [14C]linoleic acid incorporation into liver cell phospholipids and triacylglycerols. On the other hand, methyl esters of phorbol-12-myristate-13-acetate do not influence, while mercasolyl and sphingosine decrease the fatty acid incorporation into liver glycerolipids. It has been found that sphingosine abolishes the thyroxine effect on glycerolipid activation. It has been shown also that sphingosine, thyroxine and phorbol-12-myristate-13-acetate methyl esters do not influence the cholesterol ester synthesis. However, phorbol-12-myristate-13-acetate enhances the cholesterol ester activation in liver cells twofold.