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鸽动脉粥样硬化中的内皮损伤与血小板黏附

Endothelial damage and thrombocyte adhesion in pigeon atherosclerosis.

作者信息

Lewis J C, Kottke B A

出版信息

Science. 1977 May 27;196(4293):1007-9. doi: 10.1126/science.860128.

DOI:10.1126/science.860128
PMID:860128
Abstract

Scanning electron microscopy studies of spontaneously occurring atherosclerosis in pigeons reveal dramatic alterations in endothelial integrity. An irregular endothelium at the intimal cushion region of 5-week-old birds gives rise to extensive areas of pitted endothelium and subendothelial exposure. Thrombocytes, thrombocyte aggregates, and leukocytes are associated with the developing lesion.

摘要

对鸽子自然发生的动脉粥样硬化进行扫描电子显微镜研究发现,内皮完整性发生了显著改变。5周龄鸟类内膜垫区域不规则的内皮会导致内皮出现广泛的凹陷区域以及内皮下暴露。血小板、血小板聚集体和白细胞与病变发展相关。

相似文献

1
Endothelial damage and thrombocyte adhesion in pigeon atherosclerosis.鸽动脉粥样硬化中的内皮损伤与血小板黏附
Science. 1977 May 27;196(4293):1007-9. doi: 10.1126/science.860128.
2
Spontaneous endothelial cell injury in the intimal cushions of atherosclerotic pigeons.动脉粥样硬化鸽内膜垫中的自发性内皮细胞损伤。
Prog Biochem Pharmacol. 1977;13:220-4.
3
Endothelial cell proliferation and monocyte adhesion to atherosclerotic lesions of white carneau pigeons.内皮细胞增殖及单核细胞与白卡诺鸽动脉粥样硬化病变的黏附
Am J Pathol. 1986 Oct;125(1):152-60.
4
Anatomy and histology of aorta of White Carneau pigeon.
Lab Invest. 1975 Apr;32(4):536-51.
5
Morphologic characteristics of naturally occurring atherosclerosis in the brachiocephalic artery of the pigeon.
Exp Mol Pathol. 1991 Apr;54(2):99-111. doi: 10.1016/0014-4800(91)90023-q.
6
Experimental atherosclerosis: surface ultrastructural studies in the rabbit aorta.
Scan Electron Microsc. 1979(3):835-41.
7
Spontaneous atherosclerosis: an ultrastructural study in the white Carneau pigeon.自发性动脉粥样硬化:白鸽卡诺品系的超微结构研究
Virchows Arch A Pathol Anat Histol. 1977 Aug 31;375(2):147-57. doi: 10.1007/BF00428102.
8
Early atherogenesis in White Carneau pigeons. I. Leukocyte margination and endothelial alterations at the celiac bifurcation.白卡诺鸽的早期动脉粥样硬化。I. 腹腔动脉分叉处的白细胞靠边和内皮改变。
Am J Pathol. 1984 Jul;116(1):56-68.
9
Location and sequence of atherosclerotic plaque formation in white Carneau and show racer pigeons: reevaluation and redefinition.白色卡诺鸽和赛鸽动脉粥样硬化斑块形成的位置与序列:重新评估与重新定义
Arch Pathol Lab Med. 1978 Nov;102(11):581-6.
10
Effect of glucocorticoid administration early in life on aortic prostaglandin synthesis and morphology in atherosclerosis-susceptible pigeons.
Exp Clin Endocrinol. 1985 Apr;85(2):147-54. doi: 10.1055/s-0029-1210430.

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1
Rapamycin inhibits ox-LDL-induced inflammation in human endothelial cells in vitro by inhibiting the mTORC2/PKC/c-Fos pathway.雷帕霉素通过抑制 mTORC2/蛋白激酶 C/原癌基因 c-Fos 通路抑制 ox-LDL 诱导的人内皮细胞炎症反应。
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Guanosine induces necrosis of cultured aortic endothelial cells.鸟苷可诱导培养的主动脉内皮细胞坏死。
Am J Pathol. 1994 Aug;145(2):423-7.
3
Effects of chronic oral consumption of nicotine on the rabbit aortic endothelium.长期口服尼古丁对兔主动脉内皮的影响。
Am J Pathol. 1981 Feb;102(2):229-38.
4
Lipid accumulation and ultrastructural change within the aortic wall during early spontaneous atherogenesis.早期自发性动脉粥样硬化形成过程中主动脉壁内的脂质积聚和超微结构变化。
Am J Pathol. 1980 Sep;100(3):683-705.
5
Monocyte chemoattractants in pigeon aortic atherosclerosis.鸽主动脉粥样硬化中的单核细胞趋化因子
Am J Pathol. 1987 Mar;126(3):464-75.
6
Activation of coagulation releases endothelial cell mitogens.凝血的激活会释放内皮细胞促分裂原。
J Cell Biol. 1986 Aug;103(2):419-28. doi: 10.1083/jcb.103.2.419.
7
Long term clinical outcome of coronary surgery and assessment of the benefit obtained with postoperative aspirin and dipyridamole.冠状动脉手术的长期临床结果以及术后阿司匹林和双嘧达莫所获益处的评估。
Br Heart J. 1988 Aug;60(2):111-6. doi: 10.1136/hrt.60.2.111.
8
Therapeutic lidocaine concentrations have no effect on blood platelet function and plasma catecholamine levels.治疗浓度的利多卡因对血小板功能和血浆儿茶酚胺水平无影响。
Eur J Clin Pharmacol. 1992;43(1):109-11. doi: 10.1007/BF02280766.
9
Platelet-leukocyte interactions following arterial endothelial injury.动脉内皮损伤后的血小板-白细胞相互作用。
Am J Pathol. 1979 Aug;96(2):567-80.
10
The vascular endothelium-pathobiologic significance.血管内皮——病理生物学意义。
Am J Pathol. 1978 Dec;93(3):803-48.