Lewis J C, Fuster V, Kottke B A
Prog Biochem Pharmacol. 1977;13:220-4.
Since endothelial damage precedes sterol accumulation, platelet factor 4-like activity elevations and alterations in thrombocyte adhesiveness, it clearly is one of the earliest events in the pathogenesis of spontaneous pigeon atherosclerosis. Although the relationships among endothelial damage and the other events have not been elucidated, it is conceivable that products released from thrombocytes subsequent to adhesion on damaged endothelium may trigger other localized changes in the intimal cushion area and lead to the progression of atherosclerosis.
由于内皮损伤先于固醇积累、血小板因子4样活性升高和血小板黏附性改变，显然它是自发性鸽动脉粥样硬化发病机制中最早出现的事件之一。尽管内皮损伤与其他事件之间的关系尚未阐明，但可以想象，血小板在受损内皮上黏附后释放的产物可能引发内膜垫区域的其他局部变化，并导致动脉粥样硬化的进展。
