Ramanujam P S, Venkatesh K S, Co Barnett T, Fietz M J
Department of Oncology and Pathology, Walter O. Boswell Memorial Hospital, Sun City, Arizona 85351, USA.
Dis Colon Rectum. 1996 Jan;39(1):37-9. doi: 10.1007/BF02048266.
The purpose of this study was to determine the incidence of human papillomavirus deoxyribonucleic acid (HPV DNA) in anal squamous carcinoma.
HPV DNA in situ hybridization for HPV Types 6, 11, 16, 18, 31, 33, and 35 was performed on the formalin-fixed, paraffin-embedded tissue from 53 perianal and anal squamous carcinomas and 10 controls.
HPV DNA sequences were identified in 18 of 53 anal squamous carcinomas (34 percent). All 10 controls were negative for HPV DNA. Of the 18 positive patients, 10 were perianal squamous carcinomas, and 8 were anal canal squamous carcinomas. Six of the perianal carcinomas were positive for HPV Types 6 and 11. The remaining four perianal carcinomas and all eight of the anal canal carcinomas were positive for HPV Types 16 and 18.
HPV DNA sequences can be identified in anal squamous carcinomas. Anal squamous epithelium is another site where HPV infection may carry a risk for malignant transformation. One-third of anal squamous carcinomas may be associated with prior HPV infection. Patients with anogenital HPV infection should be routinely screened for anal squamous lesions.
本研究的目的是确定肛门鳞状细胞癌中人乳头瘤病毒脱氧核糖核酸（HPV DNA）的发生率。
对53例肛周和肛门鳞状细胞癌以及10例对照的福尔马林固定、石蜡包埋组织进行HPV 6、11、16、18、31、33和35型的HPV DNA原位杂交。
53例肛门鳞状细胞癌中有18例（34%）检测到HPV DNA序列。所有10例对照的HPV DNA均为阴性。在18例阳性患者中，10例为肛周鳞状细胞癌，8例为肛管鳞状细胞癌。6例肛周癌HPV 6和11型呈阳性。其余4例肛周癌和所有8例肛管癌HPV 16和18型呈阳性。
肛门鳞状细胞癌中可检测到HPV DNA序列。肛门鳞状上皮是HPV感染可能导致恶性转化风险的另一个部位。三分之一的肛门鳞状细胞癌可能与既往HPV感染有关。患有肛门生殖器HPV感染的患者应常规筛查肛门鳞状病变。
