Takano Y, Saegusa M, Ikenaga M, Mitomi H, Okayasu I
Department of Pathology Kitasato University School of Medicine, Japan.
J Cancer Res Clin Oncol. 1996;122(3):166-70. doi: 10.1007/BF01366957.
The role of apoptosis in colon cancer was investigated in terms of control of growth and expression on p53, using the nick-ended-DNA labelling method and immunohistochemistry. The apoptotic labeling index was highest in the T1 stage (24 cases), as was the proliferative activity, assessed in terms of the Ki-67 labeling index. Both labeling indices demonstrated similar overall incidence curves for the total 95 colon cancer cases, and examination of individual cases revealed a statistically significant correlation (P=0.01). However, neither index had any relation to p53. The results thus suggest that apoptosis in colon cancers has a linkage with proliferative activity that can be assessed by Ki-67 labeling, but is not regulated by the p53 system. This might contribute to the diversity of colon cancer growth.
运用缺口末端DNA标记法和免疫组织化学技术，从生长控制和p53表达方面研究了细胞凋亡在结肠癌中的作用。凋亡标记指数在T1期（24例）最高，增殖活性也是如此，增殖活性通过Ki-67标记指数评估。对于总共95例结肠癌病例，这两个标记指数均显示出相似的总体发生率曲线，对个别病例的检查显示存在统计学显著相关性（P = 0.01）。然而，两个指数均与p53无关。因此，结果表明结肠癌中的细胞凋亡与可通过Ki-67标记评估的增殖活性有关，但不受p53系统调节。这可能导致结肠癌生长的多样性。
