Eosinophilia associated with proliferation of CD(3+)4-(8-) alpha beta+ T cells with chromosome 16 anomalies.

作者信息

Kitano K, Ichikawa N, Mahbub B, Ueno M, Ito T, Shimodaira S, Kodaira H, Ishida F, Kobayashi H, Saito H, Okubo Y, Enokihara H, Kiyosawa K

机构信息

Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

出版信息

Br J Haematol. 1996 Feb;92(2):315-7. doi: 10.1046/j.1365-2141.1996.d01-1482.x.

We describe a patient with eosinophilia and an abnormal CD(3+)4-(8-) alpha beta+ T-cell population. Chromosomal analysis of sorted CD(3+)4-(8-) cells revealed abnormal karyotypes on chromosome 16. In the presence of IL-2 the production of IL-5 from CD(3+)4-(8-) cells was higher than that from CD(3+)4-(8-) cells. Eosinophil survival-enhancing activity in the patient serum was inhibited by a combination of anti-IL-5 and anti-GM-CSF monoclonal antibodies. These data suggest that increased production of IL-5 and GM-CSF from the abnormal CD(3+)4-(8-) cells might cause eosinophilia.