Yao E S, Lamont R J, Leu S P, Weinberg A
Department of Oral Biology, School of Dentistry, University of Washington, Seattle 98195, USA.
Oral Microbiol Immunol. 1996 Feb;11(1):35-41. doi: 10.1111/j.1399-302x.1996.tb00334.x.
Strong interspecies adherence was demonstrated among the periodontal pathogens Treponema denticola, Bacteroides forsythus and Porphyromonas gingivalis, and between these pathogens and the commensal plaque organism Streptococcus crista. Adherence showed specificity and demonstrated saturation binding kinetics. Binding between B. forsythus and P. gingivalis appeared to be a unimodal protein-protein interaction. Binding between the other organisms was at least bimodal involving interactions between combinations of proteins and carbohydrates with a variety of sugar specificities. Salivary molecules prevented adherence between T. denticola and S. crista, and serum eliminated B. forsythus binding to P. gingivalis. All other interactions occurred to some degree in the presence of serum and saliva. Such interbacterial binding interactions may be important in the establishment of periodontopathic plaque.
在牙周病原体齿垢密螺旋体、福赛斯坦纳菌和牙龈卟啉单胞菌之间，以及这些病原体与共生菌斑微生物嵴链球菌之间，均表现出强烈的种间黏附。黏附具有特异性，并呈现出饱和结合动力学。福赛斯坦纳菌和牙龈卟啉单胞菌之间的结合似乎是一种单峰蛋白-蛋白相互作用。其他微生物之间的结合至少是双峰的，涉及具有多种糖特异性的蛋白质和碳水化合物组合之间的相互作用。唾液分子可阻止齿垢密螺旋体与嵴链球菌之间的黏附，血清可消除福赛斯坦纳菌与牙龈卟啉单胞菌的结合。在血清和唾液存在的情况下，所有其他相互作用均在一定程度上发生。这种细菌间的结合相互作用可能在牙周病损菌斑的形成中起重要作用。
