Madsen C, Claesson M H, Röpke C
Institute of Toxicology, National Food Agency, Soeberg, Denmark.
Toxicology. 1996 Mar 18;107(3):219-27. doi: 10.1016/0300-483x(95)03244-a.
The synthetic pyrethroids deltametrin and alpha-cypermetrin were studied for effects on the immune system in 28-day studies in F344 male rats. Sixteen rats per group were dosed with either deltametrin 0, 1, 5, or 10 mg/kg body wt./day or alpha-cypermertin 0, 4, 8, or 12 mg/kg body wt./day in soy bean oil by gavage. Haematology, bone marrow cell counts, tests for natural killer (NK) cell activity and mitogen response (Con A and STM) as well as quantitation of lymphocyte subpopulations were performed. Spleen cells from immunized animals (six animals/group) were tested for antibody production (SRBC-PFC). Volumes of lymphoid compartments of mesenteric lymph nodes and thymus were estimated using stereological methods. In the deltametrin study an effect was found in the groups receiving 5 or 10 mg/kg body wt. The effects were: increased weight of mesenterial lymph nodes, decreased thymus weight in immunized animals and an increase in numbers of SRBC-PFC and splenic NK cell activity. An effect on relative adrenal weight was seen in the 10 mg/kg body wt. group. No severe effects on the immune system was found. The lowest effect level of alpha-cypermetrin was 12 mg/kg body wt./day based on increased relative adrenal weight.
在F344雄性大鼠中进行了为期28天的研究，以探讨合成拟除虫菊酯溴氰菊酯和高效氯氰菊酯对免疫系统的影响。每组16只大鼠通过灌胃给予大豆油中的溴氰菊酯0、1、5或10毫克/千克体重/天，或高效氯氰菊酯0、4、8或12毫克/千克体重/天。进行了血液学、骨髓细胞计数、自然杀伤（NK）细胞活性和丝裂原反应（伴刀豆球蛋白A和STM）测试以及淋巴细胞亚群定量。对免疫动物（每组6只动物）的脾细胞进行了抗体产生（SRBC-PFC）测试。使用体视学方法估计肠系膜淋巴结和胸腺的淋巴腔体积。在溴氰菊酯研究中，在接受5或10毫克/千克体重的组中发现了影响。这些影响包括：肠系膜淋巴结重量增加、免疫动物的胸腺重量降低、SRBC-PFC数量增加和脾NK细胞活性增加。在10毫克/千克体重组中观察到对相对肾上腺重量的影响。未发现对免疫系统有严重影响。基于相对肾上腺重量增加，高效氯氰菊酯的最低影响水平为12毫克/千克体重/天。
