Kumar Anil, Nagar Mahindra
Department of Human Structure and Neurobiology, Oman Medical College Affiliated with West Virginia University (USA), Sohar, Sultanate of Oman.
Department of Anatomy, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi 110095, India.
Toxicol Rep. 2014 Jul 15;1:401-410. doi: 10.1016/j.toxrep.2014.07.005. eCollection 2014.
Deltamethrin, a type II synthetic pyrethroid, has lead to a widespread concern over the potential adverse effects on human health. Adult Wistar albino rats, weighing 150-200 g, were divided into two groups of ten animals each. The group II rats were injected with deltamethrin (1 mg/kg body weight) intraperitoneally, for five days/week for a month. The group I were controls. Animals were sacrificed within 24 h of the last injection by perfusion under anesthesia. Paraffin sections (8 μm) were cut, and stained with hematoxylin and eosin. Histomorphometry was done. There was a decrease in the body weight but increase in the weight of the testis of rat. The mean vertical, antero-posterior and transverse diameter of the testis is reduced. The basement membrane enclosing the seminiferous tubules appeared thickened at sites. The number of seminiferous tubules per unit area is statistically significantly reduced. There was a generalized significant decrease in the diameter and the epithelium thickness (height) of the seminiferous tubules, associated collapse and distortion at sites of the tubules predominantly in the central region. The data obtained in the present work suggest that gonadal (testis) changes could seriously affect the reproductive potential of the rat.
溴氰菊酯，一种II型合成拟除虫菊酯，已引发人们对其对人类健康潜在不利影响的广泛关注。体重150 - 200克的成年Wistar白化大鼠被分为两组，每组十只动物。第二组大鼠腹腔注射溴氰菊酯（1毫克/千克体重），每周五天，持续一个月。第一组为对照组。在最后一次注射后24小时内，通过麻醉下灌注处死动物。切取8微米厚的石蜡切片，并用苏木精和伊红染色。进行组织形态计量学分析。大鼠体重下降，但睾丸重量增加。睾丸的平均垂直径、前后径和横径减小。包围生精小管的基底膜在某些部位增厚。单位面积生精小管的数量在统计学上显著减少。生精小管的直径和上皮厚度（高度）普遍显著降低，主要在中央区域的小管部位出现塌陷和扭曲。本研究获得的数据表明，性腺（睾丸）变化可能严重影响大鼠的生殖潜能。
