Nisell H, Hagskog K, Westgren M
Department of Obstetrics and Gynecology, Karolinska Insitute, Huddinge, Sweden.
Acta Obstet Gynecol Scand. 1996 Feb;75(2):132-4. doi: 10.3109/00016349609033304.
To evaluate if the presence of fibronectin in cervical secretion might provide information on the natural course of equivocal prelabor rupture of membranes (ROM) at term.
One hundred and sixteen women with a history of prelabor ROM at term but without visible amniotic fluid leakage were included in the study. The presence of fetal fibronectin in cervical secretion was determined by a commercially available kit (ROM check; limit of detection 100 ng/ml). Women with (n=49) and without (n=67) a positive fibronectin test were compared with regard to time interval between presumed membrane rupture and delivery, mode of delivery and fetal distress rates.
There was no significant difference in the time interval between presumed ROM and delivery between those with a negative fibronectin test (median: 80 hours) and those with a positive test (median: 64 hours; p=0.28, Mann-Whitney U-test). Neither were there any differences in complicated delivery or fetal distress rates.
Determination of fetal fibronectin in cervical secretion with the present method is of limited value in the clinical management of patients with equivocal rupture of the membranes.
评估宫颈分泌物中纤连蛋白的存在是否可为足月胎膜早破（ROM）不明确的自然病程提供信息。
116名有足月胎膜早破病史但无明显羊水渗漏的女性纳入研究。通过市售试剂盒（ROM检测；检测限100 ng/ml）测定宫颈分泌物中胎儿纤连蛋白的存在情况。比较纤连蛋白检测阳性（n = 49）和阴性（n = 67）的女性在推测胎膜破裂与分娩之间的时间间隔、分娩方式及胎儿窘迫率。
纤连蛋白检测阴性者（中位数：80小时）与阳性者（中位数：64小时；曼-惠特尼U检验，p = 0.28）在推测胎膜破裂与分娩之间的时间间隔上无显著差异。复杂分娩率或胎儿窘迫率也无差异。
用本方法测定宫颈分泌物中的胎儿纤连蛋白在胎膜破裂不明确患者的临床管理中价值有限。
