Sugai M, Kono R, Nakahara Y, Kunita Y, Tanaka S
Acta Pathol Jpn. 1977 Mar;27(2):185-95. doi: 10.1111/j.1440-1827.1977.tb01868.x.
The present study consists of 9 cases of idiopathic cardiomyopathy which were divided into two types, i.e. 6 cases of the hypertrophic type and 3 cases of the dilated type. The former type was found in school-children and relatively younger adults, and the latter in various ages. In both types the hearts showed marked enlargement. The characteristic gross changes of the hypertrophic type were hypertrophy of the anterior wall of left ventricle and of the ventricular septum. Microscopically, the hypertrophied myocardium demonstrated a bizarre arrangement showing different size and shape of muscle fibers. In addition, the wall of small arteries and arterioles revealed circumscribed elastosis here and there. In the dilated type, the hearts showed marked dilatation of both ventricles, and microscopy revealed coagulation necrosis of the myocardial fibers and marked scar formation with slight inflammatory cell infiltration. The gross and microscopic changes in both types of idiopathic cardiomyopathy differed from one another in several respects, and the authors assumed that the differences indicate an independent etiology of both types in man.
本研究包括9例特发性心肌病，分为两型，即肥厚型6例和扩张型3例。前者见于学龄儿童及相对年轻的成年人，后者则见于各年龄段。两型心脏均显著增大。肥厚型的特征性大体改变为左心室前壁及室间隔肥厚。显微镜下，肥厚的心肌呈现出奇异的排列，肌纤维大小和形状各异。此外，小动脉和微动脉壁可见散在的局限性弹性组织变性。在扩张型中，心脏表现为两心室显著扩张，显微镜检查显示心肌纤维凝固性坏死以及显著的瘢痕形成，伴有轻微的炎性细胞浸润。两型特发性心肌病的大体和显微镜下改变在几个方面彼此不同，作者认为这些差异表明两型在人类中有独立的病因。
