脑桥失活可阻断去大脑猫中延髓诱导的肌张力抑制。
Inactivation of the pons blocks medullary-induced muscle tone suppression in the decerebrate cat.
作者信息
Kohyama J, Lai Y Y, Siegel J M
机构信息
Dept. of Psychiatry, UCLA School of Medicine, Sepulveda VAMC, North Hills, Calif 91343, USA.
出版信息
Sleep. 1998 Nov 1;21(7):695-9. doi: 10.1093/sleep/21.7.695.
Abstract
The pontomedullary region is responsible for the reduction of muscle activity in rapid-eye-movement sleep and contributes to the control of muscle tone in waking. This study sought to clarify the nature of the interaction between the pontine and medullary reticular formation in mediating muscle tone suppression. The degree of medullary-induced neck muscle tone suppression in the decerebrate cat was assessed before and after microinjection of lidocaine into the pontine reticular formation. Medullary stimulation-induced suppression of neck muscle tone was blocked after pontine lidocaine microinjection. The maximum blockade was observed at 16.6 minutes on average after the injection, and recovery occurred within 45 minutes. We conclude that descending mechanisms from the medulla are not sufficient for the triggering of muscle tone suppression. A two-way interaction between the medulla and pons is hypothesized to play a crucial role in the control of muscle tone.
摘要
脑桥延髓区域负责在快速眼动睡眠中降低肌肉活动，并有助于在清醒时控制肌张力。本研究旨在阐明脑桥和延髓网状结构在介导肌张力抑制过程中相互作用的本质。在向脑桥网状结构微量注射利多卡因之前和之后，评估了去大脑猫中延髓诱导的颈部肌张力抑制程度。脑桥微量注射利多卡因后，延髓刺激诱导的颈部肌张力抑制被阻断。平均在注射后16.6分钟观察到最大阻断，45分钟内恢复。我们得出结论，来自延髓的下行机制不足以触发肌张力抑制。推测延髓和脑桥之间的双向相互作用在肌张力控制中起关键作用。
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