Vukicević S, Stavljenić A, Pećina M
Department of Anatomy, Zagreb University School of Medicine, Croatia.
Eur J Clin Chem Clin Biochem. 1995 Oct;33(10):661-71. doi: 10.1515/cclm.1995.33.10.661.
Significant progress has been made in the characterization of cartilage and bone differentiating proteins. A family of unique proteins known as bone morphogenetic proteins has been described, and there is ample evidence that they are directly responsible for de novo cartilage and bone formation in vivo. Extensive research is underway to develop appropriate and optimal delivery systems based on extracellular matrix components. It is likely that bone morphogenetic proteins will play a crucial role in bone and joint regeneration and repair.
在软骨和骨分化蛋白的特性研究方面已取得显著进展。已描述了一类称为骨形态发生蛋白的独特蛋白质家族，并且有充分证据表明它们在体内直接负责软骨和骨的从头形成。目前正在进行广泛研究，以开发基于细胞外基质成分的合适且最佳的递送系统。骨形态发生蛋白很可能在骨和关节的再生与修复中发挥关键作用。
