Department of Surgery-Traumatology, Leiden University Medical Center, Leiden, The Netherlands.
Int Orthop. 2011 Sep;35(9):1271-80. doi: 10.1007/s00264-011-1301-z. Epub 2011 Jun 23.
This review evaluates the application of bone morphogenetic proteins (BMPs) in delayed bone repair, aiming at a broad audience from clinicians to scientists. Next to an overview of the role of the different BMPs, their antagonists and their current applications, special attention is focused on new scientific developments improving the effects of BMP-based therapy for bone repair.
Publication searches in PubMed and Embase revealed 850 relevant articles on the criteria 'BMP' AND 'bone repair' (as of May 2011). The abstracts were carefully reviewed and papers were selected according to the content.
The resulting publications showed that BMP-2 and BMP-7 are clearly the most extensively evaluated BMPs, in general with positive results on bone healing, comparable to the use of unspecific preparations such as autologous bone grafts or platelet-rich plasma.
Although the efficacy of BMPs as stimulators of bone repair has been demonstrated in model systems and clinical studies, the use of BMPs to enhance fracture healing in the clinical setting is still controversial. Issues such as when, where and how much of which BMP is the most effective and profitable to use still have to be elucidated. But optimisation of the BMP products used in combination with cheaper production methods will inevitably stimulate the clinical use of BMPs for bone fracture healing in the near future.
本综述评估了骨形态发生蛋白（BMPs）在延迟性骨修复中的应用，目标读者群体包括临床医生和科研人员。除了概述不同 BMPs、其拮抗剂的作用以及它们的当前应用外，本综述还特别关注了新的科学进展，这些进展旨在提高基于 BMP 的骨修复治疗效果。
在 PubMed 和 Embase 上进行文献检索，根据标准“BMP”和“骨修复”（截至 2011 年 5 月）共检索到 850 篇相关文章。仔细审查了摘要，并根据内容选择了论文。
这些出版物表明，BMP-2 和 BMP-7 是研究最广泛的 BMP，它们在促进骨愈合方面通常具有积极作用，与使用自体骨移植物或富含血小板的血浆等非特异性制剂相当。
尽管 BMP 作为骨修复刺激物的功效已在模型系统和临床研究中得到证实，但在临床环境中使用 BMP 来增强骨折愈合仍然存在争议。例如，何时、何地以及使用哪种 BMP 最有效和最有利，这些问题仍有待阐明。但是，优化与更廉价的生产方法相结合使用的 BMP 产品，将不可避免地刺激 BMP 在骨骨折愈合的临床应用。
